From I-45: Take the exit for Hwy. 59 South/Hwy. 288, then go as far to the right as you can. Keep following Hwy. 59 (and staying to the right) past the branch for 288. Take the next exit (Fannin). Go straight at the light, then take any convenient right turn one block to Main.
Turn left on Main; go around the fountain, staying on Main, and turn right on Sunset (1st light after the fountain). At the fork, go left onto Rice Blvd. Follow Rice Blvd. to entrance 13 on your left; turn in, pass 2 stop signs, and park in the visitors' parking across from the Student Center (the building with the octagonal room. The con will be in Sewall Hall; signs will be posted to direct you.
From I-10: Take I-45 South to the Hwy. 59 South/Hwy. 288 exit and proceed as above.